Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for H1-10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H1-10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H1-10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:129,027,026–129,027,525 | 289.1 kb | Distal (>10kb) Multiome | 589 | |
| chr3:129,045,697–129,046,752 | 269.7 kb | Distal (>10kb) Multiome | 170 | |
| chr3:129,120,244–129,122,947 | 194.2 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,160,815–129,162,244 | 154.9 kb | Distal (>10kb) Multiome | 917 | |
| chr3:129,183,284–129,184,525 | 132.3 kb | Distal (>10kb) Multiome | 966 | |
| chr3:129,249,227–129,250,064 | 66.7 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,278,315–129,279,976 | 37.4 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,305,525–129,306,095 | 10.5 kb | Distal (>10kb) Multiome | 342 | |
| chr3:129,312,917–129,313,831 | 2.5 kb | Proximal (<10kb) | 209 | |
| chr3:129,314,154–129,316,995 | 1.3 kb | Proximal (<10kb) Multiome | 949 | |
| chr3:129,343,720–129,344,497 | 27.8 kb | Distal (>10kb) Multiome | 346 | |
| chr3:129,344,512–129,344,822 | 28.4 kb | Distal (>10kb) Multiome | 58 | |
| chr3:129,359,825–129,360,642 | 44.1 kb | Distal (>10kb) Multiome | 65 | |
| chr3:129,399,193–129,399,868 | 83.3 kb | Distal (>10kb) Multiome | 625 | |
| chr3:129,428,173–129,429,050 | 112.4 kb | Distal (>10kb) Multiome | 504 | |
| chr3:129,439,426–129,440,695 | 123.9 kb | Distal (>10kb) Multiome | 875 | |
| chr3:129,534,465–129,535,515 | 218.6 kb | Distal (>10kb) Multiome | 397 | |
| chr3:129,602,230–129,602,769 | 286.2 kb | Distal (>10kb) Multiome | 70 | |
| chr3:129,605,081–129,607,497 | 290.6 kb | Distal (>10kb) Multiome | 686 |
Genomic view of the H1-10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.