GC2

Gene Cluster 551 genes

Animal organ morphogenesis and immune response genes

This 587-gene module contains highly-published genes including TGFB1, MDM2, HLA-DQB1, HLA-A, and AGER, with enrichment in animal organ morphogenesis. Knockdown of ARID1A activates this module. Knockdown of FOXH1 represses this module.

Key terms: animal organ morphogenesis anatomical structure morphogenesis Notable genes: TGFB1 MDM2 HLA-DQB1 HLA-A AGER PTK2 MIF MAOA Top TFs: FOXH1 ARID1A SOX17 SMARCC1 CBFA2T2

551 member genes 55 TF regulators

TF Regulatory Network

Direction indicates the effect of TF knockdown on this gene cluster (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	padj	Bind	OR

Module Genes

Genes assigned to this temporal expression cluster (mfuzz).

Gene	Type	Publications