The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC42EP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC42EP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC42EP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:73,092,145–73,093,083 | 219.3 kb | Distal (>10kb) Multiome | 900 | |
| chr17:73,156,070–73,156,871 | 155.6 kb | Distal (>10kb) Multiome | 439 | |
| chr17:73,160,789–73,161,852 | 150.7 kb | Distal (>10kb) Multiome | 148 | |
| chr17:73,164,283–73,166,339 | 147.1 kb | Distal (>10kb) Multiome | 454 | |
| chr17:73,192,033–73,193,741 | 119.0 kb | Distal (>10kb) Multiome | 877 | |
| chr17:73,231,620–73,233,239 | 79.6 kb | Distal (>10kb) Multiome | 964 | |
| chr17:73,305,179–73,305,488 | 6.5 kb | Proximal (<10kb) | 411 | |
| chr17:73,310,270–73,312,686 | 1.1 kb | Proximal (<10kb) Multiome | 1078 | |
| chr17:73,317,321–73,317,925 | 5.6 kb | Proximal (<10kb) Multiome | 153 | |
| chr17:73,318,653–73,319,222 | 7.0 kb | Proximal (<10kb) Multiome | 44 | |
| chr17:73,341,495–73,342,744 | 30.2 kb | Distal (>10kb) Multiome | 347 | |
| chr17:73,342,845–73,343,860 | 31.5 kb | Distal (>10kb) Multiome | 294 | |
| chr17:73,351,620–73,352,260 | 39.9 kb | Distal (>10kb) Multiome | 17 | |
| chr17:73,359,891–73,361,657 | 49.2 kb | Distal (>10kb) Multiome | 310 | |
| chr17:73,363,301–73,364,389 | 52.0 kb | Distal (>10kb) Multiome | 140 | |
| chr17:73,492,248–73,493,566 | 180.9 kb | Distal (>10kb) Multiome | 299 | |
| chr17:73,532,274–73,532,901 | 220.6 kb | Distal (>10kb) Multiome | 213 | |
| chr17:73,533,741–73,534,375 | 222.0 kb | Distal (>10kb) Multiome | 44 | |
| chr17:73,535,674–73,537,028 | 224.9 kb | Distal (>10kb) Multiome | 50 | |
| chr17:73,566,925–73,567,719 | 255.2 kb | Distal (>10kb) Multiome | 108 | |
| chr17:73,589,468–73,590,700 | 277.8 kb | Distal (>10kb) Multiome | 209 |
Genomic view of the CDC42EP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.