The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CCNG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:76,867,647–76,869,012 | 288.8 kb | Distal (>10kb) Multiome | 115 | |
| chr4:76,896,697–76,898,709 | 259.0 kb | Distal (>10kb) Multiome | 498 | |
| chr4:76,948,267–76,951,238 | 208.2 kb | Distal (>10kb) Multiome | 968 | |
| chr4:77,012,534–77,013,096 | 144.4 kb | Distal (>10kb) Multiome | 56 | |
| chr4:77,074,968–77,076,780 | 81.0 kb | Distal (>10kb) Multiome | 1071 | |
| chr4:77,084,016–77,084,805 | 72.8 kb | Distal (>10kb) Multiome | 93 | |
| chr4:77,123,593–77,124,378 | 33.2 kb | Distal (>10kb) Multiome | 24 | |
| chr4:77,128,136–77,129,079 | 28.6 kb | Distal (>10kb) Multiome | 73 | |
| chr4:77,152,502–77,152,724 | 4.5 kb | Proximal (<10kb) | 51 | |
| chr4:77,156,523–77,158,721 | 1.0 kb | Proximal (<10kb) Multiome | 1039 | |
| chr4:77,175,021–77,175,714 | 18.2 kb | Distal (>10kb) Multiome | 259 | |
| chr4:77,193,476–77,193,939 | 36.4 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the CCNG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.