APOBEC3C

apolipoprotein B mRNA editing enzyme catalytic subunit 3C | APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

Member of: DE-4 Developmental clusters: GC6

Biological processes 22 terms

DNA cytosine deamination (GO:0070383)P-body (GO:0000932)RNA binding (GO:0003723)RNA binding (GO:0003723)clearance of foreign intracellular DNA (GO:0044355)cytidine deaminase activity (GO:0004126)cytidine to uridine editing (GO:0016554)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)defense response to symbiont (GO:0140546)defense response to virus (GO:0051607)hydrolase activity (GO:0016787)negative regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045869)negative regulation of viral genome replication (GO:0045071)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of gene expression via chromosomal CpG island demethylation (GO:0044029)protein binding (GO:0005515)transposable element silencing (GO:0010526)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating APOBEC3C 0 TFs

Transcription factors with Perturb-seq knockdown data for APOBEC3C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOBEC3C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to APOBEC3C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOBEC3C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:38,755,428–38,756,383	258.2 kb	Distal (>10kb) Multiome	770
chr22:38,793,674–38,794,378	220.1 kb	Distal (>10kb) Multiome	484
chr22:38,843,207–38,844,443	170.4 kb	Distal (>10kb) Multiome	585
chr22:38,866,394–38,866,832	147.7 kb	Distal (>10kb) Multiome	76
chr22:38,871,208–38,873,237	141.9 kb	Distal (>10kb) Multiome	758
chr22:39,014,028–39,014,530	26 bp	At TSS Multiome	367
chr22:39,020,588–39,021,215	6.7 kb	Proximal (<10kb) Multiome	149
chr22:39,040,158–39,041,304	26.7 kb	Distal (>10kb) Multiome	237
chr22:39,077,158–39,077,634	63.0 kb	Distal (>10kb) Multiome	66
chr22:39,087,857–39,088,400	73.8 kb	Distal (>10kb) Multiome	32
chr22:39,144,772–39,146,359	131.4 kb	Distal (>10kb) Multiome	668
chr22:39,152,016–39,153,700	138.5 kb	Distal (>10kb) Multiome	607
chr22:39,170,852–39,171,359	156.8 kb	Distal (>10kb) Multiome	425
chr22:39,174,292–39,175,258	160.6 kb	Distal (>10kb) Multiome	688
chr22:39,179,438–39,180,229	165.4 kb	Distal (>10kb) Multiome	84
chr22:39,229,884–39,230,835	215.9 kb	Distal (>10kb) Multiome	417
chr22:39,242,211–39,244,345	228.6 kb	Distal (>10kb) Multiome	605
chr22:39,310,537–39,311,897	296.9 kb	Distal (>10kb) Multiome	655

Genome Browser

Genomic view of the APOBEC3C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.