Predicted to enable cytoskeletal protein-membrane anchor activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including nervous system development; paranodal junction maintenance; and protein localization to axon. Located in several cellular components, including cell-cell junction; ciliary basal body; and cytosol. Implicated in esophagus squamous cell carcinoma. Biomarker of meningioma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EPB41L3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPB41L3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPB41L3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:5,294,279–5,297,100 | 247.7 kb | Distal (>10kb) Multiome | 946 | |
| chr18:5,456,606–5,457,058 | 87.2 kb | Distal (>10kb) Multiome | 201 | |
| chr18:5,538,645–5,538,819 | 4.6 kb | Proximal (<10kb) | 15 | |
| chr18:5,542,357–5,544,394 | 688 bp | At TSS Multiome | 346 | |
| chr18:5,546,716–5,546,939 | 3.3 kb | Proximal (<10kb) | 50 | |
| chr18:5,627,928–5,631,218 | 84.5 kb | Distal (>10kb) Multiome | 515 |
Genomic view of the EPB41L3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.