Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in G2/M transition of mitotic cell cycle and regulation of canonical Wnt signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CDK14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:90,345,490–90,347,070 | 249.7 kb | Distal (>10kb) Multiome | 940 | |
| chr7:90,349,263–90,349,920 | 246.7 kb | Distal (>10kb) Multiome | 169 | |
| chr7:90,403,221–90,404,177 | 192.8 kb | Distal (>10kb) Multiome | 843 | |
| chr7:90,594,353–90,594,535 | 1.8 kb | Proximal (<10kb) | 16 | |
| chr7:90,594,698–90,597,637 | 1.4 kb | Proximal (<10kb) Multiome | 788 | |
| chr7:90,621,670–90,622,257 | 25.7 kb | Distal (>10kb) Multiome | 175 | |
| chr7:90,701,500–90,702,420 | 105.6 kb | Distal (>10kb) Multiome | 104 | |
| chr7:90,850,166–90,851,075 | 254.3 kb | Distal (>10kb) Multiome | 119 |
Genomic view of the CDK14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.