Predicted to enable superoxide-generating NADPH oxidase activator activity. Involved in osteoclast fusion and superoxide metabolic process. Located in cytosol and podosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SH3PXD2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3PXD2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3PXD2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,661,427–103,661,981 | 193.9 kb | Distal (>10kb) Multiome | 301 | |
| chr10:103,692,163–103,693,782 | 163.2 kb | Distal (>10kb) Multiome | 288 | |
| chr10:103,771,858–103,772,878 | 83.1 kb | Distal (>10kb) Multiome | 532 | |
| chr10:103,829,792–103,830,463 | 25.4 kb | Distal (>10kb) Multiome | 65 | |
| chr10:103,836,976–103,837,450 | 18.4 kb | Distal (>10kb) Multiome | 52 | |
| chr10:103,839,572–103,841,382 | 15.2 kb | Distal (>10kb) Multiome | 306 | |
| chr10:103,848,006–103,848,208 | 7.4 kb | Proximal (<10kb) | 49 | |
| chr10:103,854,330–103,856,292 | 127 bp | At TSS Multiome | 649 | |
| chr10:103,859,291–103,859,683 | 3.7 kb | Proximal (<10kb) | 177 | |
| chr10:103,917,536–103,919,139 | 62.8 kb | Distal (>10kb) Multiome | 926 | |
| chr10:103,966,618–103,967,712 | 111.6 kb | Distal (>10kb) Multiome | 758 | |
| chr10:104,045,227–104,046,125 | 190.0 kb | Distal (>10kb) Multiome | 116 | |
| chr10:104,057,535–104,058,241 | 202.3 kb | Distal (>10kb) Multiome | 66 | |
| chr10:104,120,766–104,122,782 | 266.4 kb | Distal (>10kb) Multiome | 959 | |
| chr10:104,155,284–104,156,268 | 300.3 kb | Distal (>10kb) Multiome | 175 |
Genomic view of the SH3PXD2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.