PREX1

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 | KIAA1415, P-REX1

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

Member of: DE-9 DE-9.3 Developmental clusters: GC2

Biological processes 31 terms

G protein-coupled receptor signaling pathway (GO:0007186)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)actin filament polymerization (GO:0030041)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)dendritic shaft (GO:0043198)enzyme binding (GO:0019899)growth cone (GO:0030426)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)intracellular signal transduction (GO:0035556)leukocyte activation (GO:0045321)negative regulation of TOR signaling (GO:0032007)neutrophil activation (GO:0042119)perinuclear region of cytoplasm (GO:0048471)phospholipid binding (GO:0005543)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of cell migration (GO:0030335)protein binding (GO:0005515)protein serine/threonine kinase inhibitor activity (GO:0030291)reactive oxygen species metabolic process (GO:0072593)regulation of actin filament polymerization (GO:0030833)regulation of dendrite development (GO:0050773)regulation of small GTPase mediated signal transduction (GO:0051056)regulation of small GTPase mediated signal transduction (GO:0051056)superoxide metabolic process (GO:0006801)

Expression (TPM)

TFs regulating PREX1 0 TFs

Transcription factors with Perturb-seq knockdown data for PREX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PREX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PREX1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PREX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:48,620,328–48,621,446	207.1 kb	Distal (>10kb) Multiome	701
chr20:48,751,156–48,751,799	76.6 kb	Distal (>10kb) Multiome HiCAR	254
chr20:48,824,694–48,825,149	2.8 kb	Proximal (<10kb)	104
chr20:48,825,950–48,828,654	1.6 kb	Proximal (<10kb) Multiome	682
chr20:48,846,443–48,846,926	18.6 kb	Distal (>10kb) Multiome	257
chr20:48,858,252–48,858,759	30.6 kb	Distal (>10kb) Multiome	100
chr20:48,921,125–48,922,305	93.7 kb	Distal (>10kb) Multiome	1077
chr20:49,045,736–49,047,213	218.5 kb	Distal (>10kb) Multiome	1069

Genome Browser

Genomic view of the PREX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.