This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for TST. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TST upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TST, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:36,775,650–36,776,664 | 243.1 kb | Distal (>10kb) Multiome | 472 | |
| chr22:36,856,048–36,856,669 | 163.0 kb | Distal (>10kb) Multiome | 475 | |
| chr22:37,018,841–37,020,143 | 187 bp | At TSS Multiome | 684 | |
| chr22:37,051,550–37,052,220 | 32.3 kb | Distal (>10kb) Multiome | 351 | |
| chr22:37,187,959–37,189,489 | 168.9 kb | Distal (>10kb) Multiome | 340 | |
| chr22:37,198,530–37,200,140 | 180.1 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the TST locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.