The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for MTX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:175,980,827–175,982,249 | 287.9 kb | Distal (>10kb) Multiome | 156 | |
| chr2:176,001,269–176,002,875 | 267.2 kb | Distal (>10kb) Multiome | 1003 | |
| chr2:176,079,159–176,081,284 | 189.2 kb | Distal (>10kb) Multiome | 591 | |
| chr2:176,082,698–176,083,714 | 186.2 kb | Distal (>10kb) Multiome | 171 | |
| chr2:176,087,237–176,089,163 | 180.9 kb | Distal (>10kb) Multiome | 475 | |
| chr2:176,091,485–176,093,664 | 176.7 kb | Distal (>10kb) Multiome | 351 | |
| chr2:176,096,693–176,099,096 | 171.7 kb | Distal (>10kb) Multiome | 661 | |
| chr2:176,106,474–176,108,077 | 162.1 kb | Distal (>10kb) Multiome | 426 | |
| chr2:176,115,942–176,116,781 | 152.9 kb | Distal (>10kb) Multiome | 202 | |
| chr2:176,122,221–176,123,570 | 146.6 kb | Distal (>10kb) Multiome | 242 | |
| chr2:176,140,289–176,141,245 | 128.7 kb | Distal (>10kb) Multiome | 712 | |
| chr2:176,158,845–176,160,665 | 110.3 kb | Distal (>10kb) Multiome | 325 | |
| chr2:176,171,283–176,172,596 | 97.5 kb | Distal (>10kb) Multiome | 245 | |
| chr2:176,174,987–176,175,675 | 94.3 kb | Distal (>10kb) Multiome | 273 | |
| chr2:176,177,721–176,178,875 | 91.2 kb | Distal (>10kb) Multiome | 271 | |
| chr2:176,188,129–176,189,887 | 80.8 kb | Distal (>10kb) Multiome | 652 | |
| chr2:176,269,105–176,270,145 | 41 bp | At TSS Multiome | 1001 | |
| chr2:176,490,109–176,490,979 | 221.1 kb | Distal (>10kb) Multiome | 255 | |
| chr2:176,507,599–176,508,319 | 238.7 kb | Distal (>10kb) Multiome | 77 | |
| chr2:176,559,279–176,560,522 | 290.4 kb | Distal (>10kb) Multiome | 125 |
Genomic view of the MTX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.