DE-6 ›

DE-6.5

Submodule 21 genes

DNA repair and reproductive process functions

This module contains 21 genes including DAXX, RAD51C, PARP2, FANCG, and CISD2, with enrichment in reproductive process. Knockdown of FOXH1 and SOX17 activates this module. No TFs with repressive effects on this module were identified.

Key terms: cellular response to stress reproductive process response to arsenic-containing substance cellular response to arsenic-containing substance Notable genes: DAXX RAD51C PARP2 FANCG CISD2 PPIF RAD1 CDC5L Top TFs: FOXH1 SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (21)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact