The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for CISD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CISD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CISD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:102,759,924–102,761,752 | 108.0 kb | Distal (>10kb) Multiome | 907 | |
| chr4:102,826,418–102,828,875 | 40.9 kb | Distal (>10kb) Multiome | 1216 | |
| chr4:102,868,279–102,869,865 | 110 bp | At TSS Multiome | 1045 | |
| chr4:102,869,921–102,870,207 | 948 bp | At TSS | 69 | |
| chr4:103,018,881–103,020,188 | 150.7 kb | Distal (>10kb) Multiome | 882 | |
| chr4:103,075,865–103,077,254 | 207.6 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the CISD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.