This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for RAD51C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAD51C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAD51C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:58,487,466–58,488,518 | 204.8 kb | Distal (>10kb) Multiome | 222 | |
| chr17:58,513,911–58,515,157 | 178.0 kb | Distal (>10kb) Multiome | 585 | |
| chr17:58,517,239–58,519,377 | 174.6 kb | Distal (>10kb) Multiome | 1140 | |
| chr17:58,527,884–58,528,411 | 164.4 kb | Distal (>10kb) Multiome | 79 | |
| chr17:58,531,392–58,532,430 | 160.6 kb | Distal (>10kb) Multiome | 323 | |
| chr17:58,630,482–58,632,252 | 60.9 kb | Distal (>10kb) Multiome | 1257 | |
| chr17:58,657,864–58,659,830 | 33.4 kb | Distal (>10kb) Multiome | 1269 | |
| chr17:58,669,900–58,670,548 | 22.3 kb | Distal (>10kb) Multiome | 52 | |
| chr17:58,678,911–58,679,743 | 13.1 kb | Distal (>10kb) Multiome | 889 | |
| chr17:58,692,284–58,692,956 | 16 bp | At TSS Multiome | 1038 | |
| chr17:58,755,487–58,756,995 | 63.2 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the RAD51C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.