The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPIF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:79,059,142–79,059,755 | 288.0 kb | Distal (>10kb) Multiome | 478 | |
| chr10:79,066,353–79,069,731 | 280.2 kb | Distal (>10kb) Multiome | 956 | |
| chr10:79,093,590–79,094,392 | 253.6 kb | Distal (>10kb) Multiome | 583 | |
| chr10:79,129,088–79,129,986 | 218.0 kb | Distal (>10kb) Multiome | 462 | |
| chr10:79,157,212–79,158,222 | 189.7 kb | Distal (>10kb) Multiome | 633 | |
| chr10:79,195,004–79,195,734 | 151.9 kb | Distal (>10kb) Multiome | 517 | |
| chr10:79,239,374–79,240,591 | 107.1 kb | Distal (>10kb) Multiome | 318 | |
| chr10:79,242,182–79,244,115 | 104.0 kb | Distal (>10kb) Multiome | 517 | |
| chr10:79,344,555–79,345,573 | 2.6 kb | Proximal (<10kb) Multiome | 144 | |
| chr10:79,346,612–79,348,513 | 129 bp | At TSS Multiome | 939 | |
| chr10:79,444,238–79,447,010 | 98.3 kb | Distal (>10kb) Multiome | 851 | |
| chr10:79,487,460–79,487,935 | 140.3 kb | Distal (>10kb) Multiome HiCAR | 240 |
Genomic view of the PPIF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.