The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC5L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC5L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC5L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:44,126,767–44,128,943 | 260.2 kb | Distal (>10kb) Multiome | 845 | |
| chr6:44,151,741–44,152,312 | 235.7 kb | Distal (>10kb) Multiome | 575 | |
| chr6:44,185,920–44,186,571 | 201.5 kb | Distal (>10kb) Multiome | 95 | |
| chr6:44,202,490–44,203,242 | 184.9 kb | Distal (>10kb) Multiome | 229 | |
| chr6:44,216,763–44,217,285 | 170.7 kb | Distal (>10kb) Multiome | 139 | |
| chr6:44,218,945–44,220,120 | 168.1 kb | Distal (>10kb) Multiome | 799 | |
| chr6:44,223,166–44,224,465 | 164.0 kb | Distal (>10kb) Multiome | 783 | |
| chr6:44,234,203–44,235,350 | 152.9 kb | Distal (>10kb) Multiome | 499 | |
| chr6:44,237,380–44,238,386 | 149.8 kb | Distal (>10kb) Multiome | 969 | |
| chr6:44,245,610–44,248,192 | 139.7 kb | Distal (>10kb) Multiome | 1271 | |
| chr6:44,256,209–44,258,064 | 130.3 kb | Distal (>10kb) Multiome | 1042 | |
| chr6:44,264,892–44,265,788 | 122.2 kb | Distal (>10kb) Multiome | 760 | |
| chr6:44,270,373–44,271,349 | 116.7 kb | Distal (>10kb) Multiome | 166 | |
| chr6:44,275,626–44,276,572 | 111.7 kb | Distal (>10kb) Multiome | 330 | |
| chr6:44,297,234–44,298,035 | 90.0 kb | Distal (>10kb) Multiome | 356 | |
| chr6:44,312,866–44,313,523 | 74.4 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:44,342,481–44,342,962 | 45.0 kb | Distal (>10kb) Multiome | 133 | |
| chr6:44,387,185–44,388,395 | 54 bp | At TSS Multiome | 955 | |
| chr6:44,469,799–44,470,296 | 82.3 kb | Distal (>10kb) Multiome | 375 | |
| chr6:44,475,548–44,476,402 | 88.2 kb | Distal (>10kb) Multiome | 587 | |
| chr6:44,542,501–44,543,177 | 155.2 kb | Distal (>10kb) Multiome | 93 | |
| chr6:44,655,058–44,656,097 | 267.8 kb | Distal (>10kb) Multiome | 531 |
Genomic view of the CDC5L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.