This 24-gene module includes PROM1, MCM2, POLE, RNF168, and STAG2, and is enriched for genes involved in double-strand break repair, recombinational repair, DNA recombination, and sites of DNA damage and double-strand breaks. Knockdown of SETDB1, HNF1B, and GRHL2 activates this module. Knockdown of ARID1A, SMARCC1, and SOX11 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.