This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for POLE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:132,437,261–132,437,736 | 249.9 kb | Distal (>10kb) Multiome | 153 | |
| chr12:132,488,556–132,491,043 | 197.4 kb | Distal (>10kb) Multiome | 563 | |
| chr12:132,559,692–132,561,628 | 127.4 kb | Distal (>10kb) Multiome | 607 | |
| chr12:132,598,373–132,599,027 | 88.8 kb | Distal (>10kb) Multiome | 242 | |
| chr12:132,618,319–132,618,996 | 68.7 kb | Distal (>10kb) Multiome | 202 | |
| chr12:132,686,665–132,688,078 | 82 bp | At TSS Multiome | 824 | |
| chr12:132,710,174–132,711,444 | 23.4 kb | Distal (>10kb) Multiome | 940 | |
| chr12:132,761,549–132,762,490 | 74.7 kb | Distal (>10kb) Multiome | 760 | |
| chr12:132,828,453–132,829,499 | 141.7 kb | Distal (>10kb) Multiome | 930 | |
| chr12:132,887,106–132,888,371 | 200.3 kb | Distal (>10kb) Multiome | 840 | |
| chr12:132,907,962–132,909,233 | 221.3 kb | Distal (>10kb) Multiome | 481 | |
| chr12:132,955,400–132,956,621 | 268.9 kb | Distal (>10kb) Multiome | 715 | |
| chr12:132,986,063–132,986,840 | 299.0 kb | Distal (>10kb) Multiome | 840 |
Genomic view of the POLE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.