Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for NUP153. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP153 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP153, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:17,417,499–17,418,859 | 288.8 kb | Distal (>10kb) Multiome | 259 | |
| chr6:17,472,571–17,473,238 | 233.9 kb | Distal (>10kb) Multiome | 338 | |
| chr6:17,599,884–17,601,398 | 106.5 kb | Distal (>10kb) Multiome | 972 | |
| chr6:17,705,487–17,707,240 | 59 bp | At TSS Multiome | 1165 | |
| chr6:17,939,336–17,940,066 | 232.9 kb | Distal (>10kb) Multiome | 164 | |
| chr6:17,986,741–17,988,454 | 280.9 kb | Distal (>10kb) Multiome | 815 | |
| chr6:18,122,030–18,123,058 | 415.8 kb | Distal (>10kb) Multiome HiCAR | 824 |
Genomic view of the NUP153 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.