This module contains 29 genes including GRK2, PAK4, SOCS2, CSNK1E, and MAP2K7, with enrichment in nitrogen compound transport, export from cell, and secretion. Knockdown of FOXA2 activates this module, while knockdown of SOX17 and EOMES represses it. These regulatory patterns suggest that during ESC-to-DE differentiation, this secretory module is suppressed by SOX17 and EOMES but released from FOXA2-mediated inhibition.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.