The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for CSNK1E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSNK1E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSNK1E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,052,312–38,052,803 | 264.9 kb | Distal (>10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 260.1 kb | Distal (>10kb) Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 236.3 kb | Distal (>10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 219.5 kb | Distal (>10kb) Multiome | 186 | |
| chr22:38,181,365–38,182,291 | 135.5 kb | Distal (>10kb) Multiome | 676 | |
| chr22:38,201,378–38,203,636 | 115.5 kb | Distal (>10kb) Multiome | 848 | |
| chr22:38,214,397–38,215,017 | 102.6 kb | Distal (>10kb) Multiome | 382 | |
| chr22:38,272,379–38,273,237 | 44.5 kb | Distal (>10kb) Multiome | 526 | |
| chr22:38,317,171–38,317,940 | 42 bp | At TSS Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 2.1 kb | Proximal (<10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 18.8 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 36.0 kb | Distal (>10kb) Multiome | 404 | |
| chr22:38,397,757–38,399,352 | 81.5 kb | Distal (>10kb) Multiome | 345 | |
| chr22:38,455,555–38,456,345 | 138.6 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 144.2 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,505,466–38,506,961 | 189.1 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 252.9 kb | Distal (>10kb) Multiome | 559 |
Genomic view of the CSNK1E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.