This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for SOCS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOCS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOCS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:93,376,338–93,378,831 | 192.6 kb | Distal (>10kb) Multiome | 827 | |
| chr12:93,441,175–93,442,781 | 128.3 kb | Distal (>10kb) Multiome | 926 | |
| chr12:93,467,156–93,468,248 | 102.8 kb | Distal (>10kb) Multiome | 844 | |
| chr12:93,564,287–93,564,590 | 5.8 kb | Proximal (<10kb) | 179 | |
| chr12:93,569,457–93,573,628 | 499 bp | At TSS Multiome | 1052 | |
| chr12:93,677,025–93,678,145 | 107.1 kb | Distal (>10kb) Multiome | 999 | |
| chr12:93,741,675–93,742,916 | 172.0 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr12:94,101,224–94,102,767 | 532.1 kb | Distal (>10kb) Multiome HiCAR | 674 |
Genomic view of the SOCS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.