MAP2K7
mitogen-activated protein kinase kinase 7 | Jnkk2, MKK7, SAPKK4, PRKMK7

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Member of: DE-6 DE-6.2
Biological processes 40 terms
ATP binding (GO:0005524)Fc-epsilon receptor signaling pathway (GO:0038095)JNK cascade (GO:0007254)JNK cascade (GO:0007254)JUN kinase kinase activity (GO:0008545)JUN kinase kinase activity (GO:0008545)JUN kinase kinase activity (GO:0008545)MAP kinase kinase activity (GO:0004708)MAP kinase kinase activity (GO:0004708)cellular senescence (GO:0090398)cellular senescence (GO:0090398)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)enzyme binding (GO:0019899)magnesium ion binding (GO:0000287)magnesium ion binding (GO:0000287)mitogen-activated protein kinase binding (GO:0051019)mitogen-activated protein kinase binding (GO:0051019)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of MAPK cascade (GO:0043410)positive regulation of telomere maintenance (GO:0032206)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein phosphatase binding (GO:0019903)protein serine kinase activity (GO:0106310)protein tyrosine kinase activity (GO:0004713)response to UV (GO:0009411)response to heat (GO:0009408)response to osmotic stress (GO:0006970)response to tumor necrosis factor (GO:0034612)signal transduction (GO:0007165)stress-activated MAPK cascade (GO:0051403)stress-activated MAPK cascade (GO:0051403)stress-activated protein kinase signaling cascade (GO:0031098)
Expression (TPM)
MAP2K7 — as a Regulated Gene

TFs regulating MAP2K7 0 TFs

Transcription factors with Perturb-seq knockdown data for MAP2K7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP2K7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MAP2K7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP2K7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:7,629,285–7,629,891 274.2 kb Distal (>10kb) Multiome 650
chr19:7,636,753–7,637,571 266.8 kb Distal (>10kb) Multiome 689
chr19:7,680,480–7,681,546 223.1 kb Distal (>10kb) Multiome 679
chr19:7,829,238–7,830,666 74.0 kb Distal (>10kb) Multiome 621
chr19:7,853,168–7,853,781 50.4 kb Distal (>10kb) Multiome 747
chr19:7,861,607–7,864,383 41.1 kb Distal (>10kb) Multiome 348
chr19:7,868,454–7,870,252 34.4 kb Distal (>10kb) Multiome 721
chr19:7,871,072–7,872,772 31.7 kb Distal (>10kb) Multiome 487
chr19:7,873,962–7,875,061 29.2 kb Distal (>10kb) Multiome 416
chr19:7,888,334–7,888,798 15.4 kb Distal (>10kb) Multiome 509
chr19:7,902,730–7,904,931 100 bp At TSS Multiome 1000
chr19:7,917,358–7,918,182 14.1 kb Distal (>10kb) Multiome 316
chr19:7,919,934–7,921,640 16.8 kb Distal (>10kb) Multiome 802
chr19:7,924,612–7,926,698 21.4 kb Distal (>10kb) Multiome 766
chr19:7,943,338–7,944,472 40.0 kb Distal (>10kb) Multiome 974
chr19:8,001,954–8,002,874 98.7 kb Distal (>10kb) Multiome 475
chr19:8,005,202–8,006,197 101.9 kb Distal (>10kb) Multiome 729
chr19:8,028,908–8,029,518 125.5 kb Distal (>10kb) Multiome 122
chr19:8,050,174–8,051,154 146.9 kb Distal (>10kb) Multiome 467
chr19:8,148,316–8,149,986 245.7 kb Distal (>10kb) Multiome 381
chr19:8,203,277–8,204,384 300.1 kb Distal (>10kb) Multiome 150

Genome Browser

Genomic view of the MAP2K7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:7,619,285 – 8,214,384
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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