The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for PIM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:49,852,925–49,854,755 | 107.1 kb | Distal (>10kb) Multiome | 864 | |
| chr22:49,917,887–49,919,285 | 42.3 kb | Distal (>10kb) Multiome | 736 | |
| chr22:49,934,630–49,935,498 | 25.4 kb | Distal (>10kb) Multiome | 298 | |
| chr22:49,935,964–49,936,517 | 24.7 kb | Distal (>10kb) Multiome | 637 | |
| chr22:49,959,889–49,961,612 | 311 bp | At TSS Multiome | 843 | |
| chr22:49,961,773–49,962,968 | 1.7 kb | Proximal (<10kb) Multiome | 708 | |
| chr22:49,999,173–50,000,437 | 38.9 kb | Distal (>10kb) Multiome | 237 | |
| chr22:50,030,288–50,030,739 | 69.7 kb | Distal (>10kb) Multiome | 433 | |
| chr22:50,169,918–50,170,446 | 209.5 kb | Distal (>10kb) Multiome | 245 | |
| chr22:50,184,288–50,186,776 | 225.1 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 240.2 kb | Distal (>10kb) Multiome | 612 | |
| chr22:50,244,340–50,245,635 | 284.3 kb | Distal (>10kb) Multiome | 868 | |
| chr22:50,250,480–50,251,917 | 290.6 kb | Distal (>10kb) Multiome | 683 |
Genomic view of the PIM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.