This module contains 12 genes including SIAH1, RBM10, BICD2, PLEKHG2, and SP2, with enrichment in protein ubiquitination and RNA binding processes. Knockdown of FOXA2 activates this module, while knockdown of SOX17, EOMESODERMIN, and GATA6 repress it. These TF perturbations suggest the module is normally suppressed during endoderm differentiation and becomes activated when FOXA2 function is lost.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.