This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BICD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BICD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BICD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:92,669,446–92,670,794 | 94.6 kb | Distal (>10kb) Multiome | 870 | |
| chr9:92,745,472–92,746,004 | 19.2 kb | Distal (>10kb) Multiome | 60 | |
| chr9:92,757,529–92,757,859 | 7.0 kb | Proximal (<10kb) | 33 | |
| chr9:92,764,048–92,765,970 | 226 bp | At TSS Multiome | 941 | |
| chr9:92,768,903–92,769,097 | 4.1 kb | Proximal (<10kb) | 9 | |
| chr9:92,808,165–92,809,496 | 44.2 kb | Distal (>10kb) Multiome | 398 | |
| chr9:92,877,587–92,878,337 | 113.3 kb | Distal (>10kb) Multiome | 591 | |
| chr9:93,058,154–93,059,241 | 293.8 kb | Distal (>10kb) Multiome | 417 |
Genomic view of the BICD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.