This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SIAH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIAH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIAH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:48,117,171–48,117,887 | 267.8 kb | Distal (>10kb) Multiome | 334 | |
| chr16:48,244,113–48,244,792 | 141.1 kb | Distal (>10kb) Multiome | 957 | |
| chr16:48,365,312–48,366,772 | 19.4 kb | Distal (>10kb) Multiome | 826 | |
| chr16:48,383,885–48,384,266 | 1.1 kb | Proximal (<10kb) | 323 | |
| chr16:48,384,395–48,386,081 | 40 bp | At TSS Multiome | 865 | |
| chr16:48,609,338–48,610,591 | 224.7 kb | Distal (>10kb) Multiome | 827 | |
| chr16:48,623,055–48,623,916 | 238.0 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the SIAH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.