This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for RBM10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:46,903,672–46,904,257 | 241.3 kb | Distal (>10kb) Multiome | 417 | |
| chrX:46,912,095–46,913,434 | 232.7 kb | Distal (>10kb) Multiome | 558 | |
| chrX:47,129,095–47,129,667 | 15.9 kb | Distal (>10kb) Multiome | 538 | |
| chrX:47,144,621–47,145,590 | 133 bp | At TSS Multiome | 649 | |
| chrX:47,190,608–47,191,059 | 45.5 kb | Distal (>10kb) Multiome | 536 | |
| chrX:47,191,642–47,192,226 | 46.8 kb | Distal (>10kb) Multiome | 138 | |
| chrX:47,193,067–47,193,943 | 48.5 kb | Distal (>10kb) Multiome | 651 | |
| chrX:47,217,449–47,219,337 | 72.8 kb | Distal (>10kb) Multiome | 736 | |
| chrX:47,232,860–47,233,865 | 88.3 kb | Distal (>10kb) Multiome | 684 | |
| chrX:47,321,409–47,321,883 | 176.4 kb | Distal (>10kb) Multiome | 127 | |
| chrX:47,361,756–47,362,456 | 216.9 kb | Distal (>10kb) Multiome | 297 | |
| chrX:47,381,691–47,382,470 | 236.9 kb | Distal (>10kb) Multiome | 17 |
Genomic view of the RBM10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.