This 55-gene module includes BRCA1, EZH2, CHEK1, PRKDC, and CCNE1, with strong enrichment for DNA replication, DNA repair, replication fork function, and DNA helicase activity. Knockdown of RCOR2 activates this module. No repressing transcription factors were identified.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.