This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for UHRF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UHRF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UHRF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,633,303–4,633,826 | 276.0 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 273.1 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 270.1 kb | Distal (>10kb) Multiome | 710 | |
| chr19:4,669,686–4,671,221 | 239.1 kb | Distal (>10kb) Multiome | 797 | |
| chr19:4,678,652–4,679,681 | 230.3 kb | Distal (>10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 185.5 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:4,791,166–4,792,360 | 118.0 kb | Distal (>10kb) Multiome | 897 | |
| chr19:4,867,260–4,868,220 | 41.7 kb | Distal (>10kb) Multiome | 718 | |
| chr19:4,908,827–4,910,489 | 491 bp | At TSS Multiome | 766 | |
| chr19:4,968,227–4,969,595 | 59.4 kb | Distal (>10kb) Multiome | 764 | |
| chr19:5,048,124–5,048,589 | 138.9 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the UHRF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.