This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for PITPNA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PITPNA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PITPNA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:1,268,002–1,268,635 | 294.5 kb | Distal (>10kb) Multiome | 644 | |
| chr17:1,399,339–1,400,718 | 162.5 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,455,335–1,456,916 | 106.4 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,484,963–1,486,119 | 77.4 kb | Distal (>10kb) Multiome | 562 | |
| chr17:1,487,906–1,488,733 | 74.6 kb | Distal (>10kb) Multiome | 597 | |
| chr17:1,490,717–1,492,156 | 71.3 kb | Distal (>10kb) Multiome | 675 | |
| chr17:1,515,722–1,517,330 | 46.0 kb | Distal (>10kb) Multiome | 796 | |
| chr17:1,562,314–1,563,047 | 37 bp | At TSS Multiome | 685 | |
| chr17:1,589,843–1,590,457 | 27.3 kb | Distal (>10kb) Multiome | 538 | |
| chr17:1,627,811–1,629,617 | 65.9 kb | Distal (>10kb) Multiome HiCAR | 753 | |
| chr17:1,642,697–1,644,482 | 80.5 kb | Distal (>10kb) Multiome | 467 | |
| chr17:1,648,163–1,650,244 | 86.4 kb | Distal (>10kb) Multiome | 932 | |
| chr17:1,684,343–1,685,342 | 122.1 kb | Distal (>10kb) Multiome | 728 | |
| chr17:1,710,017–1,710,765 | 147.6 kb | Distal (>10kb) Multiome | 500 | |
| chr17:1,713,886–1,717,908 | 154.7 kb | Distal (>10kb) Multiome | 1042 | |
| chr17:1,724,373–1,725,206 | 161.9 kb | Distal (>10kb) Multiome | 720 | |
| chr17:1,829,368–1,830,287 | 267.1 kb | Distal (>10kb) Multiome | 660 |
Genomic view of the PITPNA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.