This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for GPR39. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR39 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR39, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:132,304,630–132,305,296 | 112.0 kb | Distal (>10kb) Multiome | 133 | |
| chr2:132,352,429–132,353,438 | 64.1 kb | Distal (>10kb) Multiome HiCAR | 115 | |
| chr2:132,391,950–132,392,884 | 24.4 kb | Distal (>10kb) Multiome | 159 | |
| chr2:132,402,879–132,404,615 | 12.4 kb | Distal (>10kb) Multiome | 204 | |
| chr2:132,407,700–132,408,225 | 8.6 kb | Proximal (<10kb) | 13 | |
| chr2:132,412,100–132,412,350 | 4.5 kb | Proximal (<10kb) | 12 | |
| chr2:132,415,626–132,417,484 | 207 bp | At TSS Multiome | 784 | |
| chr2:132,419,142–132,420,313 | 2.3 kb | Proximal (<10kb) | 55 | |
| chr2:132,543,726–132,544,708 | 127.4 kb | Distal (>10kb) Multiome | 107 | |
| chr2:134,207,448–134,208,149 | 1791.1 kb | Distal (>10kb) Multiome HiCAR | 259 |
Genomic view of the GPR39 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.