This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for ADAM19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAM19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAM19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:157,328,291–157,328,932 | 247.2 kb | Distal (>10kb) Multiome | 311 | |
| chr5:157,571,621–157,571,878 | 3.9 kb | Proximal (<10kb) | 194 | |
| chr5:157,574,429–157,574,761 | 1.0 kb | Proximal (<10kb) | 94 | |
| chr5:157,574,988–157,576,496 | 140 bp | At TSS Multiome | 533 | |
| chr5:157,576,685–157,577,923 | 910 bp | At TSS | 109 | |
| chr5:157,578,486–157,578,806 | 2.7 kb | Proximal (<10kb) | 21 | |
| chr5:157,651,151–157,652,376 | 76.0 kb | Distal (>10kb) Multiome | 337 | |
| chr5:157,670,928–157,672,025 | 95.7 kb | Distal (>10kb) Multiome | 295 | |
| chr5:157,731,147–157,732,116 | 155.8 kb | Distal (>10kb) Multiome HiCAR | 887 | |
| chr5:157,743,286–157,744,563 | 167.9 kb | Distal (>10kb) Multiome HiCAR | 750 | |
| chr5:157,858,538–157,859,484 | 283.3 kb | Distal (>10kb) Multiome | 749 | |
| chr5:159,099,838–159,101,146 | 1524.7 kb | Distal (>10kb) Multiome HiCAR | 500 |
Genomic view of the ADAM19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.