This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for LPP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:187,737,384–187,742,012 | 413.2 kb | Distal (>10kb) Multiome HiCAR | 974 | |
| chr3:187,744,634–187,746,096 | 407.7 kb | Distal (>10kb) Multiome HiCAR | 917 | |
| chr3:187,750,052–187,750,795 | 402.9 kb | Distal (>10kb) Multiome HiCAR | 613 | |
| chr3:187,989,510–187,990,198 | 163.3 kb | Distal (>10kb) Multiome | 260 | |
| chr3:188,049,203–188,050,110 | 103.6 kb | Distal (>10kb) Multiome | 67 | |
| chr3:188,149,671–188,149,914 | 3.4 kb | Proximal (<10kb) | 10 | |
| chr3:188,152,533–188,155,009 | 761 bp | At TSS Multiome | 878 | |
| chr3:188,202,552–188,202,768 | 9.9 kb | Proximal (<10kb) | 64 | |
| chr3:188,206,020–188,206,331 | 6.4 kb | Proximal (<10kb) | 195 | |
| chr3:188,208,121–188,208,439 | 4.3 kb | Proximal (<10kb) | 88 | |
| chr3:188,216,824–188,217,451 | 4.1 kb | Proximal (<10kb) | 62 | |
| chr3:188,947,146–188,948,983 | 794.5 kb | Distal (>10kb) Multiome HiCAR | 630 |
Genomic view of the LPP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.