DE-3 ›

DE-3.39

Submodule 11 genes

Lipid metabolism and membrane transport processes

This 11-gene module includes PLD1, SLC39A8, GALC, MXI1, and CCBE1, with enrichment in lipid metabolism and membrane transport. Knockdown of FOXA2 activates this module, while knockdown of SOX17, EOMES, and GATA4 repress it. The module suggests coordinated regulation of phospholipid signaling and zinc/lipid transport pathways during endoderm differentiation.

Key terms: detoxification of cadmium ion stress response to cadmium ion plasma membrane selenite transport galactosylceramide catabolic process Notable genes: PLD1 SLC39A8 GALC MXI1 CCBE1 SEZ6L GPATCH2L ENSG00000246225

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (10)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact