This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for PLD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:171,771,073–171,771,539 | at TSS | At TSS | 201 | |
| chr3:171,809,388–171,811,048 | 120 bp | At TSS Multiome | 995 | |
| chr3:171,829,986–171,830,451 | 19.8 kb | Distal (>10kb) Multiome | 553 | |
| chr3:171,935,156–171,936,124 | 125.3 kb | Distal (>10kb) Multiome | 174 | |
| chr3:172,038,874–172,041,199 | 229.1 kb | Distal (>10kb) Multiome | 971 |
Genomic view of the PLD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.