Transcription factors with Perturb-seq knockdown data for ENSG00000246225. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000246225 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000246225, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:22,624,646–22,626,344 | 203.7 kb | Distal (>10kb) Multiome | 909 | |
| chr11:22,829,227–22,830,360 | 405 bp | At TSS Multiome | 805 | |
| chr11:22,832,980–22,833,130 | 3.5 kb | Proximal (<10kb) | 50 | |
| chr11:22,922,303–22,923,887 | 93.5 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the ENSG00000246225 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.