This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for SLC39A8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC39A8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC39A8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:100,738,073–100,738,998 | 1607.0 kb | Distal (>10kb) Multiome HiCAR | 172 | |
| chr4:101,152,402–101,153,947 | 1192.5 kb | Distal (>10kb) Multiome HiCAR | 157 | |
| chr4:102,319,212–102,320,155 | 25.7 kb | Distal (>10kb) Multiome | 159 | |
| chr4:102,340,733–102,341,693 | 3.5 kb | Proximal (<10kb) | 31 | |
| chr4:102,342,195–102,343,229 | 2.0 kb | Proximal (<10kb) | 328 | |
| chr4:102,343,901–102,346,340 | 47 bp | At TSS Multiome | 949 | |
| chr4:102,430,899–102,431,874 | 85.8 kb | Distal (>10kb) Multiome | 452 | |
| chr4:102,493,204–102,493,987 | 148.0 kb | Distal (>10kb) Multiome | 194 | |
| chr4:102,500,438–102,502,654 | 156.2 kb | Distal (>10kb) Multiome | 906 |
Genomic view of the SLC39A8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.