Predicted to be involved in synapse maturation. Predicted to act upstream of or within activation of protein kinase C activity; adult locomotory behavior; and cerebellar Purkinje cell layer development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including glutamatergic synapse; neuronal cell body; and postsynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SEZ6L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEZ6L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEZ6L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:26,066,271–26,067,073 | 102.8 kb | Distal (>10kb) Multiome | 120 | |
| chr22:26,068,692–26,069,369 | 100.5 kb | Distal (>10kb) Multiome | 61 | |
| chr22:26,168,982–26,169,926 | 82 bp | At TSS Multiome | 188 | |
| chr22:26,170,905–26,171,088 | 1.4 kb | Proximal (<10kb) | 152 | |
| chr22:26,174,435–26,174,644 | 5.0 kb | Proximal (<10kb) | 59 | |
| chr22:26,428,616–26,429,779 | 259.7 kb | Distal (>10kb) Multiome | 481 |
Genomic view of the SEZ6L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.