Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPATCH2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPATCH2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPATCH2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:75,972,579–75,973,063 | 179.2 kb | Distal (>10kb) Multiome | 56 | |
| chr14:75,982,219–75,983,158 | 169.3 kb | Distal (>10kb) Multiome | 459 | |
| chr14:75,985,670–75,986,242 | 166.0 kb | Distal (>10kb) Multiome | 373 | |
| chr14:76,136,532–76,137,578 | 14.9 kb | Distal (>10kb) Multiome | 100 | |
| chr14:76,138,216–76,139,123 | 13.1 kb | Distal (>10kb) Multiome | 309 | |
| chr14:76,151,503–76,152,617 | 41 bp | At TSS Multiome | 754 | |
| chr14:76,313,693–76,314,977 | 162.4 kb | Distal (>10kb) Multiome | 88 | |
| chr14:76,403,008–76,403,704 | 251.4 kb | Distal (>10kb) Multiome | 16 |
Genomic view of the GPATCH2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.