This 12-gene module includes APP, CUX1, PTPRG, and MAGI1, with enrichment in cell adhesion and neurite outgrowth processes. Knockdown of SMAD3 and ARID1A activates this module. Knockdown of SOX17, SMAD5, DR1, HES1, and HNF1B represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.