The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPRG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPRG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPRG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:61,537,391–61,538,223 | 24.0 kb | Distal (>10kb) Multiome | 195 | |
| chr3:61,558,672–61,558,864 | 2.7 kb | Proximal (<10kb) | 6 | |
| chr3:61,559,599–61,560,161 | 1.4 kb | Proximal (<10kb) | 189 | |
| chr3:61,560,267–61,562,525 | 135 bp | At TSS Multiome | 881 | |
| chr3:61,562,851–61,563,799 | 1.7 kb | Proximal (<10kb) Multiome | 261 | |
| chr3:61,564,095–61,564,989 | 3.2 kb | Proximal (<10kb) Multiome | 251 | |
| chr3:61,688,019–61,689,022 | 126.9 kb | Distal (>10kb) Multiome | 278 | |
| chr3:61,704,659–61,705,388 | 143.5 kb | Distal (>10kb) Multiome | 178 | |
| chr3:61,796,100–61,796,633 | 234.7 kb | Distal (>10kb) Multiome HiCAR | 99 |
Genomic view of the PTPRG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.