The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. [provided by RefSeq, Dec 2019]
Transcription factors with Perturb-seq knockdown data for FGF12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGF12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGF12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:191,328,360–191,330,803 | 1080.2 kb | Distal (>10kb) Multiome HiCAR | 982 | |
| chr3:191,962,212–191,963,983 | 446.2 kb | Distal (>10kb) Multiome HiCAR | 299 | |
| chr3:192,079,789–192,080,717 | 329.2 kb | Distal (>10kb) Multiome HiCAR | 187 | |
| chr3:192,407,949–192,410,910 | at TSS | At TSS | 543 | |
| chr3:192,416,820–192,417,542 | 7.2 kb | Proximal (<10kb) | 76 | |
| chr3:192,417,677–192,417,893 | 8.1 kb | Proximal (<10kb) | 37 | |
| chr3:192,514,040–192,515,974 | 105.4 kb | Distal (>10kb) Multiome | 442 | |
| chr3:192,700,672–192,701,436 | 291.5 kb | Distal (>10kb) Multiome | 132 | |
| chr3:192,726,996–192,728,170 | 318.0 kb | Distal (>10kb) Multiome | 320 | |
| chr3:192,788,635–192,789,830 | 379.7 kb | Distal (>10kb) Multiome | 148 | |
| chr3:192,916,263–192,918,554 | 508.4 kb | Distal (>10kb) Multiome | 705 | |
| chr3:192,930,670–192,931,143 | 521.3 kb | Distal (>10kb) Multiome | 150 |
Genomic view of the FGF12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.