This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADCY2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:6,818,419–6,819,319 | 577.4 kb | Distal (>10kb) Multiome HiCAR | 115 | |
| chr5:7,261,044–7,261,664 | 134.9 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr5:7,268,880–7,270,186 | 126.4 kb | Distal (>10kb) Multiome HiCAR | 87 | |
| chr5:7,392,089–7,392,733 | 3.4 kb | Proximal (<10kb) | 132 | |
| chr5:7,394,056–7,396,946 | 60 bp | At TSS Multiome | 276 |
Genomic view of the ADCY2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.