The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAGI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAGI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAGI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:65,356,392–65,357,157 | 682.1 kb | Distal (>10kb) Multiome | 135 | |
| chr3:65,368,876–65,369,448 | 669.8 kb | Distal (>10kb) Multiome | 51 | |
| chr3:65,401,276–65,401,739 | 637.4 kb | Distal (>10kb) Multiome | 37 | |
| chr3:65,411,307–65,412,923 | 627.3 kb | Distal (>10kb) Multiome | 143 | |
| chr3:65,548,852–65,549,844 | 489.5 kb | Distal (>10kb) Multiome | 283 | |
| chr3:65,596,992–65,598,468 | 441.4 kb | Distal (>10kb) Multiome | 289 | |
| chr3:65,854,685–65,855,673 | 183.6 kb | Distal (>10kb) Multiome | 332 | |
| chr3:65,902,215–65,902,816 | 136.2 kb | Distal (>10kb) Multiome | 121 | |
| chr3:65,950,226–65,950,881 | 88.3 kb | Distal (>10kb) Multiome | 135 | |
| chr3:65,953,020–65,953,813 | 85.3 kb | Distal (>10kb) Multiome | 435 | |
| chr3:66,036,263–66,037,233 | 1.6 kb | Proximal (<10kb) | 208 | |
| chr3:66,037,331–66,039,992 | 183 bp | At TSS Multiome | 825 | |
| chr3:66,220,628–66,221,378 | 182.1 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the MAGI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.