This module contains 13 genes including MDM4, POT1, DCAF1, ZDHHC17, and TTI1, with top enriched terms related to DNA damage response, protein ubiquitination, and cellular stress pathways. Knockdown of SOX17, NANOG, and OCT4 activates this module. Knockdown of FOXA2, GATA4, and GATA6 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.