Involved in positive regulation of DNA damage checkpoint and regulation of TOR signaling. Located in cytoplasm. Part of TORC1 complex; TORC2 complex; and TTT Hsp90 cochaperone complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:37,845,138–37,846,093 | 187.9 kb | Distal (>10kb) Multiome | 127 | |
| chr20:37,914,632–37,915,455 | 118.4 kb | Distal (>10kb) Multiome | 382 | |
| chr20:38,033,115–38,034,182 | 98 bp | At TSS Multiome | 1021 | |
| chr20:38,165,098–38,165,562 | 131.9 kb | Distal (>10kb) Multiome | 707 | |
| chr20:38,260,290–38,261,046 | 227.2 kb | Distal (>10kb) Multiome | 161 |
Genomic view of the TTI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.