Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PPP4R3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP4R3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP4R3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:91,252,762–91,254,136 | 257.1 kb | Distal (>10kb) Multiome | 429 | |
| chr14:91,264,238–91,265,162 | 245.8 kb | Distal (>10kb) Multiome | 276 | |
| chr14:91,302,942–91,304,213 | 207.0 kb | Distal (>10kb) Multiome | 215 | |
| chr14:91,413,560–91,414,125 | 96.7 kb | Distal (>10kb) Multiome | 171 | |
| chr14:91,417,256–91,419,093 | 91.5 kb | Distal (>10kb) Multiome | 961 | |
| chr14:91,509,196–91,511,114 | 20 bp | At TSS Multiome | 1071 |
Genomic view of the PPP4R3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.