Enables histone H2AT120 kinase activity; nuclear estrogen receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including cell competition in a multicellular organism; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of primary metabolic process. Located in COP9 signalosome; fibrillar center; and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DCAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:50,611,315–50,612,530 | 888.0 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr3:50,615,997–50,617,867 | 882.9 kb | Distal (>10kb) Multiome HiCAR | 754 | |
| chr3:51,384,278–51,385,586 | 114.9 kb | Distal (>10kb) Multiome | 787 | |
| chr3:51,390,699–51,392,749 | 108.8 kb | Distal (>10kb) Multiome | 824 | |
| chr3:51,499,159–51,500,640 | 102 bp | At TSS Multiome | 838 | |
| chr3:51,502,079–51,502,339 | 2.1 kb | Proximal (<10kb) | 229 | |
| chr3:51,538,310–51,539,294 | 38.7 kb | Distal (>10kb) Multiome | 974 | |
| chr3:51,670,855–51,672,297 | 171.2 kb | Distal (>10kb) Multiome | 799 | |
| chr3:51,681,945–51,682,394 | 182.2 kb | Distal (>10kb) Multiome | 291 | |
| chr3:51,706,614–51,707,579 | 207.0 kb | Distal (>10kb) Multiome | 506 | |
| chr3:51,798,234–51,798,899 | 298.7 kb | Distal (>10kb) Multiome | 120 |
Genomic view of the DCAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.