Enables calcium ion binding activity and calcium-dependent phospholipid binding activity. Involved in several processes, including insulin receptor signaling pathway; intracellular protein transmembrane transport; and positive regulation of protein targeting to membrane. Located in several cellular components, including centriolar satellite; cytoplasmic vesicle membrane; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for C2CD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2CD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2CD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:22,245,670–22,246,345 | 298.1 kb | Distal (>10kb) Multiome | 45 | |
| chr12:22,333,730–22,336,157 | 208.6 kb | Distal (>10kb) Multiome | 600 | |
| chr12:22,353,447–22,354,267 | 190.3 kb | Distal (>10kb) Multiome | 141 | |
| chr12:22,376,592–22,377,286 | 167.2 kb | Distal (>10kb) Multiome | 149 | |
| chr12:22,436,588–22,437,692 | 106.9 kb | Distal (>10kb) Multiome | 80 | |
| chr12:22,443,250–22,443,763 | 100.6 kb | Distal (>10kb) Multiome | 286 | |
| chr12:22,543,368–22,545,088 | 353 bp | At TSS Multiome | 1040 | |
| chr12:22,624,339–22,626,265 | 80.9 kb | Distal (>10kb) Multiome | 1049 | |
| chr12:22,699,795–22,700,629 | 155.7 kb | Distal (>10kb) Multiome | 93 | |
| chr12:22,700,769–22,701,762 | 157.1 kb | Distal (>10kb) Multiome | 149 |
Genomic view of the C2CD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.